3 edition of Mechanism of B lymphocyte tolerance. found in the catalog.
Mechanism of B lymphocyte tolerance.
|Series||Immunological reviews ;, v. 43|
|LC Classifications||QR188.4 .M43|
|The Physical Object|
|Pagination||280 p. :|
|Number of Pages||280|
|LC Control Number||80480813|
Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus. Mazari L(1), Ouarzane M, Zouali M. Author information: (1)Institut National de la Santé et de la Recherche Médicale, U, University of Paris 6, F Paris, France. Once stimulated by binding to a foreign antigen, such as a component of a bacterium or virus, a lymphocyte multiplies into a clone of identical of the cloned B cells differentiate into plasma cells that produce antibody molecules. These antibodies are closely modeled after the receptors of the precursor B cell, and, once released into the blood and lymph, they bind to the target.
Abstract. Normal, but not tolerant, adult thymocytes prevented particulate antigen inducing tolerance in differentiating B lymphocytes. This was demonstrated by measuring the emergence of responsive B cells (identified by their allotype) developing from a foetal liver innoculum in irradiated hosts with or without the addition of antigen, thymocytes or tolerant thymocytes. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
XIV Immunological Tolerance A. Historical Perspective B. Target Cells for Tolerance Induction C. Mechanisms of Tolerance Induction in Either T or B Lymphocytes D. Interrelationships among the Alternative Pathways to Unresponsiveness E. Relationships of the Alternative Pathways to Induction and Maintenance of Self-Tolerance F. Concluding Remarks. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel cturer: Springer.
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Edward J. Moticka PhD, in A Historical Perspective on Evidence-Based Immunology, Clonal Anergy. A second mechanism for the development of central B lymphocyte tolerance is through a process known as clonal anergy. In immunology, anergy is defined as the lack of responsiveness to an antigen despite the presence of antigen-specific lymphocytes.
Mechanism of B lymphocyte tolerance. Home. WorldCat Home About WorldCat Help. Mechanism of B lymphocyte tolerance. book Search. Search for Library Items Search for Lists Search for Contacts Search for a Library.
Create Book: ISBN: OCLC Number: Description: pages: illustrations ; 24 cm. Series Title: Immunological reviews, v. This chapter discusses the mechanism involved in B-cell lymphocyte tolerance. B lymphocytes have two antigen-specific functions in the immune response: (1) antibody formation and (2) receptor-mediated antigen uptake for presentation to major histocompatibility complex (MHC) class II-restricted T by: Central tolerance, also known as negative selection, is the process of eliminating any developing T or B lymphocytes that are reactive to self.
Through elimination of autoreactive lymphocytes, tolerance ensures that the immune system does not attack self peptides. Lymphocyte maturation (and central tolerance) occurs in primary lymphoid organs such as the bone marrow and the thymus.
B Lymphocyte. B lymphocytes produce Abs that may directly neutralize viral particles, or that can act indirectly by triggering other effector mechanisms such as phagocytosis, activation of the complement cascade, inducing Ab-dependent cellular cytotoxicity, or.
In lymphocytes, integration of Ca 2+ and other signaling pathways results in productive activation, while unopposed Ca 2+ signaling leads to tolerance or anergy. We show that the Ca 2+-regulated transcription factor NFAT has an integral role in both aspects of lymphocyte 2+ /calcineurin signaling induces a limited set of anergy-associated genes, distinct from genes induced in.
Uri Galili PhD, in The Natural Anti-Gal Antibody As Foe Turned Friend In Medicine, Tolerance induction in memory anti-Gal B cells by wild-type lymphocytes presenting α-gal epitopes. The basic mechanisms of B cell tolerance to self-antigen include clonal deletion, receptor editing in the differentiation stage of immature B cells (i.e., B cells in the bone marrow), and anergy of B cells.
The receptor editing is a major mechanism of central tolerance in B cells. If a T lymphocyte produces a self-reactive receptor, different mechanisms are initiated to induce the apoptosis of this self-reactive cell (negative regulation). B cell central tolerance is regulated by the mechanisms of receptor editing and apoptosis, which operate in succession over the course of 2 to 3 days.
T and B Lymphocytes: Recognition and Function is the 16th volume of the ICN-UCLA Symposia on Molecular and Cellular Biology. This book is organized into seven sections, encompassing 74 chapters that summarize molecular level progress in the field of immunobiology.
B lymphocyte tolerance, B lymphocyte immune tolerance. B cell tolerance is a state in which B cells do not initiate an immune response to an antigen. Typically this term refers to absence of. nisms that maintain tolerance to self-antigens in patients with lupus, a systemic autoimmune disease that can be triggered by medications taken to treat a variety of conditions.
Here, we tested the effect of hydralazine, an antihypertensive drug that triggers lupus, on receptor editing, a chief mechanism of B lymphocyte tolerance to self-antigens. Here, we tested the effect of hydralazine, an antihypertensive drug that triggers lupus, on receptor editing, a chief mechanism of B lymphocyte tolerance to self-antigens.
Using mice expressing transgenic human Igs, we found that hydralazine impairs up-regulation of RAG-2 gene expression and reduces secondary Ig gene rearrangements. Mechanisms of Lymphocyte Activation and Immune Regulation XI B Cell Biology Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells.
*immediately available upon purchase as print book shipments may. Signaling mechanisms regulating B-lymphocyte activation and tolerance Article (PDF Available) in Journal of Molecular Medicine March with 1, Reads How we measure 'reads'. Immunological tolerance only affects a subpopulation of the antigen specific B lymphocytes: Evidence against clonal deletion as the mechanism of tolerance and induction.
Immunol. Rev. 43, 1. In the B lymphocyte compartment, several mechanisms have been identified. They include clonal deletion of autoreactive lymphocytes, clonal anergy, which converts autoreactive cells to a state that precludes them from becoming activated, and receptor editing, a mechanism that modifies self-reactive B cells and renders them nonautoreactive (3.
Mechanisms of Lymphocyte Activation and Immune Regulation III Developmental Biology of Lymphocytes. Editors Search within book. Front Matter. Pages i-ix. PDF. Mechanism of Tolerance Inductions.
Thymic Mechanisms for Inducing Tolerance to Mls. Fred Ramsdell, Tracy Lantz, Frances Hausman, B. Fowlkes. B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
They function in the humoral immunity component of the adaptive immune system by secreting antibodies. Additionally, B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines.
In mammals, B cells mature in the bone marrow, which is at. Overview; As discussed in B-cell Development and T-cell Development, lymphocytes whose antigen-receptor can bind self-antigen are "eliminated".Elimination of auto-reactive lymphocytes can occur by one of four mechanisms discussed below.
Deletion; Deletion is the most straight-forward mechanism of tolerance and involves induction of cell death in auto-reactive lymphocytes. Immunological Reviews No. 43, Mechanisms of B Lymphocyte Tolerance By M. R. Potter Get PDF (0 MB).The book is divided into 5 different sections.
Section I deals with signaling pathways in B lymphocytes. It includes a contemporary assessment of B cell antigen receptor structures, and discussion of the role of Ig-a/lg-B polypeptides in linking the antigen receptor to intracellular signal transduction pathways.B.
Lymphocyte Tolerance Models. The main characteristics of B-cell tolerance are summarized in Table Experimental evidence supporting both anergy and clonal deletion as mechanisms leading to B-cell tol-erance has been obtained in transgenic mouse models.
1. Models for B-Cell Anergy.